Research achievements (PUBLICATIONS)

Basic information

Name TAKEI Tomohiko

Name of dissertation

Transient deactivation of dorsal premotor cortex or parietal area 5 impairs feedback control of the limb in macaques.

Name of author

Tomohiko Takei , Stephen G Lomber , Douglas J Cook , Stephen H Scott

Name of publication

Current biology : CB

Publisher

 

Volume (No.)

 

Issue (No.)

 

Start page

 

 

 

End page

 

Publication date

2021-02-10

Presence/absence of peer review

maru

Presence/absence of invitation

Batu

Language of publication used

English

Posting category

Overseas

Type of publication

Research Paper (Scientific Journal)

Type of authorship

Joint Work(First Author)

ISSN

 

DOI

10.1016/j.cub.2021.01.049

NAID (CiNii ID)

 

PMID

33592191

Permalink

URL

Summary

We can generate goal-directed motor corrections with surprising speed, but their neural basis is poorly understood. Here, we show that temporary cooling of dorsal premotor cortex (PMd) impaired both spatial accuracy and the speed of corrective responses, whereas cooling parietal area 5 (A5) impaired only spatial accuracy. Simulations based on optimal feedback control (OFC) models demonstrated that "deactivation" of the control policy (reduction in feedback gain) and state estimation (reduction in Kalman gain) caused impairments similar to that observed for PMd and A5 cooling, respectively. Furthermore, combined deactivation of both cortical regions led to additive impairments of individual deactivations, whereas reducing the amount of cooling to PMd led to impairments in response speed but not spatial accuracy, both also predicted by OFC models. These results provide causal support that frontoparietal circuits beyond primary somatosensory and motor cortices are involved in generating goal-directed motor corrections.

Remarks